Based on the theoretical and conceptual considerations, the vision from the research in entrepreneurship, the review of institutional conditions and the analysis of relationships between variables in this topic, the proposal was developed a pilot model of dynamic and innovative entrepreneurship which is presented based on an articulating axis called the Entrepreneurship Center for the Pilot University of Colombia, Alto Magdalena section. The methodological approach accounts for triangulation of quantitative and qualitative information, which began with a documentary review of current regulations on the potential that education and research have for entrepreneurship, as well as its articulation with the structure determined by the State and existing needs regarding the transfer of knowledge from the university to the productive and social sector and continued with the development of institutional discussion processes, contrasting the information gathered with the perceptions of the process actors. In this framework, the variables that made up the line of research were determined, which were: the entrepreneur, the environment and the relationships between the entrepreneur and the environment through the actions of the entrepreneurial acts. Thus, it is concluded that the importance of strengthening entrepreneurship research is evident by improving its quantitative and qualitative levels and defining a real and meaningful course or argument to support all kinds of policies and projects in support of the subject, based on the Fundamental development triad: university, business and State.
